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4.5.1 Angiogenesis and novel factors involved in the regulation of MB spreading The TME is responsible for the presence of several growth factors that can allow the generation of new blood vessels, such as vascular endothelial growth factor (VEGF) that in turn are essential for the growth and possible spreading of cancer cells (237, 238)

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[12] All patients should be evaluated by a healthcare professional to ensure none of the above contraindications or precautions apply